Chat nakamera

SIZE: 748 amino acids; 82568 Da DISEASE: Swiss Prot: P28329 # Defects in CHAT are the cause of familial infantile myasthenia gravis 2 (FIMG2) [MIM:254210, 254200]; also known as CMS-EA.FIMG2 patients have myasthenic symptoms since birth or early infancy, negative tests for anti-ACh R antibodies, and abrupt episodic crises with increased weakness, bulbar paralysis, and apnea precipitated by undue exertion, fever, or excitement. SIMILARITY: Swiss Prot: P28329 ## Belongs to the carnitine/choline acetyltransferase family.About 21% of all synaptic boutons (n=347) detected in tissue that was stained for Vglut1 and Ch AT were positive for Vglut1, and 14% of the Vglut1 synapses were made on cholinergic profiles.From separate cases stained for Vglut2 and Ch AT, 35% of all synaptic boutons (n=466) were positive for Vglut2, and 23% of the Vglut2 synapses were made on cholinergic profiles.Cardiac sympathetic denervation is found in various cardiac pathologies; however, its relationship with myocardial injury has not been thoroughly investigated.

We examined glutamatergic axon terminals in the sublenticular substantia innominata in rats using double-immunolabeling for vesicular glutamate transporters (Vglut1 and Vglut2) and choline acetyltransferase (Ch AT) at the electron microscopic level.Mecobalamin alleviated inflammatory and myocardial damage by protecting myocardial sympathetic nerves.The basal forebrain (BF) comprises morphologically and functionally heterogeneous cell populations, including cholinergic and non-cholinergic corticopetal neurons that are implicated in sleep-wake modulation, learning, memory and attention.Three of the four described splice variants encode identical 69 k Da proteins while one variant encodes both the 69 k Da and a larger 82 k Da protein.FUNCTION: Swiss Prot: P28329 # Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl Co A and choline at cholinergic synapses.

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